The controllable synthesis and formation mechanism of amorphous nanomaterials with regular morphology has long been an internationally recognized challenge. We have developed a series of universal preparation methods for amorphous nanomaterials by overcoming the difficulty of inducing oriented growth because of their isotropic nature, thus achieving a breakthrough in this field.Subsequently, we revealed the long-range disordered structure, formation mechanism and structure-activity relationship of amorphous nanomaterials from the atomic scale. Enlightened by our discovery by far, we are still striving to enrich the database of amorphous nanomaterials.